Synthetic toolbox: Synthetic biology

Applications

This page reproduces content from B. Wiltschi and A. Glieder, Synthetic Biology for Organic Syntheses, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 14, pp. 165-179.. It is copyright to the Royal Society of Chemistry (RSC) and is reproduced here with their express permission. If you wish to reproduce it elsewhere you must obtain similar permission from the RSC.

This approach has already found its way into industrial scale production of a variety of important molecules such as the production of insulin from E. coli and more recently in the production of naturally occurring bio-products such as the plastic monomers succinic acid and lactic acid, and n-butanol as a solvent and next generation biofuel.[1] This area is still in its nascence, but as it begins to mature it has the potential to carry significant impact on the green credentials of the pharmaceutical and fine chemical industry. A review on recent developments in the field of synthetic biology in the pharmaceutical industry has  been published by Breitling and Takano.[2]

  1. B. Wiltschi and A. Glieder, Synthetic Biology for Organic Syntheses, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 14, pp. 165-179.
  2. R. Breitling and E. Takano, Synthetic biology advances for pharmaceutical production, Curr. Opin. Biotechnol., 2015, 35, 46-51.