Synthetic toolbox: Flow chemistry

Summary and further reading

In summary, flow chemistry offers a viable and in certain cases superior alternative to batch processes; offering increased safety, efficiency and scalability. The application of continuous flow methods on process scale has seen rapid take up in recent years, and the research communities have been developing these approaches further to expand their scope of application.  

Recommended reading:

J. A. Blacker, J. R. Breen, R. A. Bourne and C. A. Hone, The Growing Impact of Continuous Flow Methods on the Twelve Principles of Green Chemistry, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 12, pp. 140-155.

Reviews on the developments in flow chemistry and more detailed information on their advantages over batch reactors can be found in the following papers:

S. G. Newman and K. F. Jensen, The role of flow in green chemistry and engineering, Green Chem., 2013, 15, 1456-1472.

C. Wiles and P. Watts, Continuous flow reactors: a perspective, Green Chem., 2012, 14, 38-54.

S. V. Ley, On Being Green: Can Flow Chemistry Help?, Chem. Rec., 2012, 12, 378-390.