Summary and further reading
In this module we have seen that many enzymes can be applied in biocatalytic retrosynthetic analysis, and it is important that this is applied more often in route design, combining bio and chemo-catalysts to design new routes to target molecules. To achieve this there are some remaining challenges in the field, including the identification of reactions not available in the enzyme tool box and the design of new biocatalysts with broad substrate scope, that are highly active and stable under chemical process conditions, via the combination of enzyme engineering with bioinformatic methods.
Biocatalysis for Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 15, pp. 180-191.,
Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis, Chem. Soc. Rev., 2012, 41, 1585-1605.,
On the development of new biocatalytic processes for practical pharmaceutical synthesis, Curr. Opin. Chem. Biol., 2013, 17, 284-292.,
Enzyme Catalysis in Organic Synthesis, (ed. ) Wiley-VCH Verlag GmbH & Co. KGaA, 2012.
Biocatalysis in Organic Synthesis, Science of Synthesis (ed. ) vol. 1, 2015.
Biotransformation in Organic Chemistry, Springer Verlag, Sixth., 2011.,
Organic Synthesis: The Disconnection Approach, John Wiley and Sons, 2008.,
Biocatalytic retrosynthesis, Nat Chem Biol, 2013, 9, 285-288.,
Industrial Methods for the Production of Optically Active Intermediates, Angew. Chem. Int. Ed., 2004, 43, 788-824.,
New Generation of Biocatalysts for Organic Synthesis, Angew. Chem. Int. Ed., 2014, 53, 3070-3095.,
Engineering the third wave of biocatalysis, Nature, 2012, 485, 185-194.,
Combining the ‘two worlds’ of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media, Curr. Opin. Chem. Biol., 2014, 19, 171-179.,