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Use of solvents
Issues surrounding solvent use
Multiple choice questions
Summary and further reading
Which of the following processes in the pharmaceutical industry typically use solvents?
Dissolution of reagents
Cleaning of equipment
Purification of product
Analytical assessment of product purity
Assessment of physical properties of product
Which of the following are strategies to reduce the environmental impact of solvents?
Remove all processes that use solvents
Recycling of solvent
Reduce volume of solvent used in a process where possible
Use only non-volatile solvents
Avoid complex solvent mixtures
Use solvent for fuel after use
Use of water instead of organic solvent
What practical considerations need to be taken into account when selecting a solvent?
Which of the following penalties can occur as a result of unpermitted solvent release to the atmosphere?
Blocking supply of the solvent in question
The company/facility being fined
Barring sale of the product arising from the process
Shutting down of a process or facility
Sealing up of exhaust flues
Which of the following are advantages of CO
as a solvent?
Easy to remove
Which of the following are disadvantages of supercritical CO
Requires high pressure
Requires specialist equipment
Doesn’t cover full spectrum of solvent parameters
Requires high temperature
Which of the following are advantages of ionic liquids?
Widely used in industry
Many options available
Safety Data Sheet information very well known
Which of the following are disadvantages of ionic liquids?
Arising from multiple synthetic steps
Recycling typically requires other solvent usage
Excessive use of critical elements
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