Summary and further reading
There are a range of different techniques that can be employed for reaction work-up and product, each with their own associated advantages and disadvantages. In this module we have seen evidence to demonstrate that it is important to think holistically about a process as a whole and ensure that the impact of work-up/down stream processing is not ignored.
Practical Process Research and Development: a guide for Organic Chemists, Academic Press, 2nd edn., 2012.,
Assessing the Benefits of Direct Isolation Processes, Org. Process Res. Dev., 2004, 8, 260-265.,
Removal of Reaction Solvent by Extractive Workup: Survey of Water and Solvent Co-extraction in Various Systems, Org. Process Res. Dev., 2007, 11, 160-164.,
A “Bottom-Up” Approach to Process Development: Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes, Org. Process Res. Dev., 2001, 5, 508-513.,
Solvent Miscibility table (Last accessed: ).
Liquid-liquid extraction (Last accessed: ).
Potential of Homogeneous Pd Catalyst Separation by Ceramic Membranes. Application to Downstream and Continuous Flow Processes, Org. Process Res. Dev., 2016, 20, 911–920.,
The use of ultra- and nanofiltration techniques in homogeneous catalyst recycling, Acc. Chem. Res., 2002, 35, 798-810.,
Extending Ru-BINAP Catalyst Life and Separating Products from Catalyst Using Membrane Recycling, Org. Process Res. Dev., 2009, 13, 863-869.,
Cyclic Peptide Formation in Reduced Solvent Volumes via In-Line Solvent Recycling by Organic Solvent Nanofiltration, Org. Process Res. Dev., 2015, 19, 841-848.,
Implications of Continuous Manufacturing and Crystallisation (Last accessed: ).
Regulatory and Quality Considerations for Continuous Manufacturing. May 20–21, 2014 Continuous Manufacturing Symposium, J. Pharm. Sci., 2015, 104, 803-812.,
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance. May 20–21, 2014 Continuous Manufacturing Symposium, J. Pharm. Sci., 2015, 104, 781-791.,
Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization, Org. Process Res. Dev., 2015, 19, 1186-1202.,
From Batch to Continuous Chemical Synthesis—A Toolbox Approach, Org. Process Res. Dev., 2014, 18, 1286-1294.,