Guides and metrics: Solvent selection guides

Summary and further reading

Solvent selection guides are widely available and can be readily integrated into everyday practice to improve the environmental acceptability of, for example, our reactions, work-ups and purifications.  

It is however worth bearing in mind the limitations of such guides and a more in depth look at solvents, including factors to be taken into consideration when selecting a solvent, issues surrounding the use of solvents and solvent replacement strategies are covered in Solvents.

Links to Guides and Recommended reading:

D. Prat, A. Wells, J. Hayler, Sneddon, C. R. McElroy, S. Abou-Shehada and P. J. Dunn, CHEM21 selection guide of classical- and less classical-solvents, Green Chem., 2016, 18, 288–296.

F. P. Byrne, S. Jin, G. Paggiola, T. H. M. Petchey, J. H. Clark, T. J. Farmer, A. J. Hunt, C. Robert McElroy and J. Sherwood, Tools and techniques for solvent selection: green solvent selection guides, Sustain Chem Process, 2016, 4, 1034–1058.

C. M. Alder, J. D. Hayler, R. K. Henderson, A. M. Redman, L. Shukla, L. E. Shuster and H. F. Sneddon, Updating and further expanding GSK's solvent sustainability guide, Green Chem., 2016.

K. Alfonsi, J. Colberg, P. J. Dunn, T. Fevig, S. Jennings, T. A. Johnson, P. H. Kleine, C. Knight, M. A. Nagy, D. A. Perry and M. Stefaniak, Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation, Green Chem., 2008, 10, 31-36.

D. Prat, O. Pardigon, H. - W. Flemming, S. Letestu, V. Ducandas, P. Isnard, E. Guntrum, T. Senac, S. Ruisseau, P. Cruciani and P. Hosek, Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes, Org. Process Res. Dev., 2013, 17, 1517-1525.

L. J. Diorazio, D. R. J. Hose and N. K. Adlington, Toward a More Holistic Framework for Solvent Selection, Org. Process Res. Dev., 2016, 20, 760-773.

J. P. Taygerly, L. M. Miller, A. Yee and E. A. Peterson, A convenient guide to help select replacement solvents for dichloromethane in chromatography, Green Chem., 2012, 14, 3020-3025.

D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents, Green Chem., 2012, 14, 3016-3019.

J. H. Clark, A. J. Hunt, L. Moity and J. Sherwood, Renewable Solvent Selection in Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 3, pp. 28-40.

H. F. Sneddon, Tools for Facilitating More Sustainable Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry : Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, L. Summerton, H. F. Sneddon, L. C. Jones and J. H. Clark, Royal Society of Chemistry, Cambridge, UK, 2016, ch. 2, pp. 12-27.