Summary and further reading
Solvent selection guides are widely available and can be readily integrated into everyday practice to improve the environmental acceptability of, for example, our reactions, work-ups and purifications.
It is however worth bearing in mind the limitations of such guides and a more in depth look at solvents, including factors to be taken into consideration when selecting a solvent, issues surrounding the use of solvents and solvent replacement strategies are covered in Solvents.
Links to Guides and Recommended reading:
CHEM21 selection guide of classical- and less classical-solvents, Green Chem., 2016, 18, 288–296.,
Tools and techniques for solvent selection: green solvent selection guides, Sustain Chem Process, 2016, 4, 1034–1058.,
Updating and further expanding GSK's solvent sustainability guide, Green Chem., 2016.,
Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation, Green Chem., 2008, 10, 31-36.,
Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes, Org. Process Res. Dev., 2013, 17, 1517-1525.,
Toward a More Holistic Framework for Solvent Selection, Org. Process Res. Dev., 2016, 20, 760-773.,
A convenient guide to help select replacement solvents for dichloromethane in chromatography, Green Chem., 2012, 14, 3020-3025.,
Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents, Green Chem., 2012, 14, 3016-3019.,
Renewable Solvent Selection in Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, The Royal Society of Chemistry, 2016, ch. 3, pp. 28-40.,
Tools for Facilitating More Sustainable Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry : Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, , Royal Society of Chemistry, Cambridge, UK, 2016, ch. 2, pp. 12-27.,