Guides and metrics: Solvent selection guides

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Solvent selection guides

A number of solvent selection guides have been published with the purpose of promoting the uptake of more sustainable solvents.  These guides give the user a quick method of identifying problematic solvents and subsequently recommending preferred alternatives. Whilst it is important to have a sound understanding of issues and the wider implications surrounding the solvents you use in your research, it is not necessarily practical to spend significant amounts of time analysing each individual substance.  One of the advantages of using selection guides is that the data collection and analysis has already been performed. The individual ranking or grouping within the guides allows you to make an informed decision as to the most appropriate choice for your needs.  Efforts have been made recently to consolidate and combine solvent guidance.  A list of guides and other recommended reading can be found here.

Learning Objectives

By the end of this module you should:

  • Understand why solvent selection guides have been developed within the pharmaceutical industry;
  • Be aware of available solvent selection guides, and the discrepancies between them;
  • Describe the criteria used in devising such guides, and the resulting benefits and limitations;
  • Be able to use them in specific case studies;
  • Be aware of specific guidance available for special classes of reaction.