Guides and metrics: Reagent guides

Summary and further reading

This page reproduces content from H. F. Sneddon, Tools for Facilitating More Sustainable Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry : Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, L. Summerton, H. F. Sneddon, L. C. Jones and J. H. Clark, Royal Society of Chemistry, Cambridge, UK, 2016, ch. 2, pp. 12-27.It is copyright to the Royal Society of Chemistry (RSC) and is reproduced here with their express permission. If you wish to reproduce it elsewhere you must obtain similar permission from the RSC.

Reagent selection guides can provide assistance in a variety of ways.  They can identify alternatives to reagents whose use may be becoming increasingly restricted by legislation; or constrained by individual company targets surrounding reducing usage of materials of concern.  They can also assist with the identification of reagents with more benign risk phrases that hence have lower EHS implications as well as those with fewer operational complexities.  They also highlight reagents /procedures which are more atom efficient and can signpoint chemists to reagents that can be used in more benign solvents.  Reagent guides provide generalised advice on common reaction classes.  More in-depth advice on the scope and utility of specific reagents is beginning to improve and can be accessed through databases and publications exploring the strengths and limitations of reagents.

Recommended reading:

H. F. Sneddon, Tools for Facilitating More Sustainable Medicinal Chemistry, in Green and Sustainable Medicinal Chemistry : Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry, L. Summerton, H. F. Sneddon, L. C. Jones and J. H. Clark, Royal Society of Chemistry, Cambridge, UK, 2016, ch. 2, pp. 12-27.

J. P. Adams, C. M. Alder, I. Andrews, A. M. Bullion, M. Campbell-Crawford, M. G. Darcy, J. D. Hayler, R. K. Henderson, C. A. Oare, I. Pendrak, A. M. Redman, L. E. Shuster, H. F. Sneddon and M. D. Walker, Development of GSK's reagent guides - embedding sustainability into reagent selection, Green Chem., 2013, 15, 1542-1549.

K. Alfonsi, J. Colberg, P. J. Dunn, T. Fevig, S. Jennings, T. A. Johnson, P. H. Kleine, C. Knight, M. A. Nagy, D. A. Perry and M. Stefaniak, Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation, Green Chem., 2008, 10, 31-36.

R. K. Henderson, A. P. Hill, A. M. Redman and H. F. Sneddon, Development of GSK's acid and base selection guides, Green Chem., 2015, 17, 945-949.

F. I. McGonagle, D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Development of a solvent selection guide for aldehyde-based direct reductive amination processes, Green Chem., 2013, 15, 1159-1165.

D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide, Green Chem., 2013, 15, 596-600.